Amgen: Prolia Shows Greater Fracture Risk Reduction Than With Alendronate In Real-world Study

05/08/2023

All singing, dancing and lasting – children rule in New King single

New King

Fun, catchy and lasting, the ‘New King’ single composed by London- based children’s author and teacher Banji Alexander is a must-listen, capturing the King’s Coronation from a child’s perspective in a unique musical memento.

The vibrant mix features string and horn sections reminiscent of 70s disco/soul blended with a pop hook, hip hop groove and funk bass line. Banji’s soulful vocal weaves into those of his young, all singing and dancing protégés creating a very timely hit.

“Having a new monarch ascend to the throne is such a historic moment, it made me want to mark that in a fun and engaging way for my primary aged audience. It is also the first song to be taken from my next book, which is a musical, also titled, ‘New King’,” says Banji.

During the last seven months he has visited 75 schools giving young people a voice by asking them: “If you were king from today, how would you celebrate?”.

Those conversations sparked the idea for his song and gathering a group of from those he had met they recorded his Coronation song and formed a collective now known as Banji’s Class – for them a very modern fairy tale come true.

Casualties Reported In New Wave Of Missile, Drone Attacks In Ukraine

Casualties were reported in a fresh wave of missile and drone attacks carried out by Russian forces across Ukraine since Sunday night.

At least one person was killed in the port city of Odesa, while five people were injured in capital Kyiv.

Other targeted cities include Kharkiv, Kherson, and Mykolaiv.

“Around midnight, the Russian occupiers attacked Odesa Oblast with Tu-22M3 long-range bombers. A total of eight missiles were launched from the area of Cape Tarkhankut (occupied Crimea). Some of the missiles did not reach their targets,” the Ukrainian air force said in a statement.

“A guard at the warehouse where an enemy missile hit was killed. His body was found under the rubble,” the spokesman for the head of the regional military administration wrote on Telegram.

Russia launched 61 air strikes and 52 long range missiles aimed at troop positions and populated areas, according to the Ukrainian military.

Ukraine claimed that it repelled the Russian attacks and downed a most-modern hypersonic weapon.

Meanwhile, the head of the annexed eastern Ukrainian region of Donetsk announced that it exported the first grain shipment from the port of Mariupol.

Casualties Reported In New Wave Of Missile, Drone Attacks In Ukraine

Casualties were reported in a fresh wave of missile and drone attacks carried out by Russian forces across Ukraine since Sunday night.

At least one person was killed in the port city of Odesa, while five people were injured in capital Kyiv.

Other targeted cities include Kharkiv, Kherson, and Mykolaiv.

“A guard at the warehouse where an enemy missile hit was killed. His body was found under the rubble,” the spokesman for the head of the regional military administration wrote on Telegram.

Russia launched 61 air strikes and 52 long range missiles aimed at troop positions and populated areas, according to the Ukrainian military.

Ukraine claimed that it repelled the Russian attacks and downed a most-modern hypersonic weapon.

Meanwhile, the head of the annexed eastern Ukrainian region of Donetsk announced that it exported the first grain shipment from the port of Mariupol.

Catalent Stock Tanks 25% As It Expects To "Significantly" Reduce 2023 Forecast

Shares of Catalent, Inc. (CTLT) are slipping 25% on Monday morning after the contract drug maker said it expects to “significantly” reduce to its 2023 forecasts for revenue and adjusted EBITDA.

CTLT is currently trading at $35.85, down $11.90 or 24.93%, on the Nasdaq, on a volume of 8.5 million shares, above average volume of 3 million. The stock opened its trading at $49.70 after closing Friday’s trading at $47.75. The stock has traded between $34.37 and $115.33 in the past 52-week period.

The company said that it expects to significantly reduce both its fiscal 2023 net revenue and Adjusted EBITDA guidance by more than $400 million each, “when combining the operational and productivity issues, the prior forecasting challenges, and, less significantly, the potential non-cash adjustments.

Further, the company expects that its income statement and balance sheet will reflect a goodwill impairment in consumer health business of more than $200 million, primarily related to its October 2021 acquisition of Bettera Wellness.

The company now expects to release financial results for the third quarter before the market open on Monday, May 15, 2023, instead of Tuesday, May 9.

Amgen: Prolia Shows Greater Fracture Risk Reduction Than With Alendronate In Real-world Study

Amgen (AMGN) said new data from a real-world study of nearly half of a million postmenopausal women with osteoporosis in the U.S. medicare program showed Prolia injection reduced fracture risk in patients versus oral alendronate. Treatment with Prolia was also associated with greater reductions in fracture risk over time, the company noted.

Prolia is the first approved therapy that specifically targets RANK Ligand, an essential regulator of bone-removing cells. Amgen said these findings provide important insights into the effectiveness of Prolia versus oral alendronate on osteoporotic fracture outcomes in post-menopausal women with osteoporosis at high risk for fracture using real-world data.

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